Abstract: 【Abstract】Objective To investigate the influential factors of thrombosis in native arteriovenous fistula (AVF) in maintenance hemodialysis patients. Methods 46 patients were recruited as case group when their AVF were thrombed at the first time. 92 patients whose AVF were conducted at the same time with the ratio 2:1 of each matched case were also recruited as control group. The clinical and biochemical data of the two groups were analyzed by analysis of variance, binary logistic regression analysis and survival analysis. Result Age, diabetes, AVF location, anastomosis, hemodialysis frequency, hemodialysis time, hypotension, hemoglobin, hematocrit, platelet, triglyceride, calcium-phosporous product, cardio-cerebrovascular disease and carnitine were statistically significant difference between the two groups. By logistic regression analysis, diabetes and calcium-phosporous product were the risk factors of AVF thrombosis, but carnitine was the protective factor. The median survival of AVF was 496 days for patients who had regularly injected carnitine, while for the non-carnitine injected patients the median survival time was 272 days, p value was 0.001. Conclusion Diabetes and calcium-phosporous product could be the risk factors of AVF thrombosis, and carnitine injected may be a protective factor.

Key words: hemodialysis, arteriovenous fistula, carnitine, match study