Abstract: 【Abstract】Objective: To investigate the relationship between the level of inflammation factors in blood serum and the heart construction and function from CHD patients.Methods: To detect the levels of hsCRP, IL-6, TNF-α in in blood serum from CHD patients. The patients were divided into two experiment groups depending on the level of hsCRP, the normal group and the abnormal group. The parameters of LAD, LVDd, LVDs, LVPWT, IVST, LVMI, LVEF, E/A, CO were measured from the two experiment groups by color Doppler ultrasonoscope.Results: Compared with the normal hsCRP group, patients have high levels of IL-6 and TNF-α in in blood serum from abnormal hsCRP group(P<0.01).Contrast to the normal hsCRP group, the levels of LAD, LVDd, LVDs, LVPWT, IVST and LVMI from abnormal hsCRP group is more higher than that from normal group( P< 0.05). The incidence of left ventricular disfunction, including hypertrophy, contractile hypofunction, ventricular compliance from abnormal hsCRP group is more higher than that from normal group( P< 0.01). The dependability analysis between inflammation factors in blood serum and the heart parameters showed that the levels of hsCRP, IL6,T NF-αhave positive correlation with LAD、LVDd、LVDs、LVPWT、IVST、LVMI (P< 0.05), but negative correlation with LVEF、E/A、CO (P< 0.05). And the level of hsCRP has positive correlation with IL-6 and T NF-α(P< 0.05).Conclusion: The level of inflammation factors in blood serum maybe is correlative to the heart construction and function from CHD patients, which is helpful to the diagnose and therapy for ESRD patients.

Key words: Hemodialysis, Inflammation, Cardiac function