Abstract: Objective :To study the relationship between high-sensitivity C-reactive protein level and intima-media thickness variability on different peritoneal permeability of the maintenance peritoneal dialysis patients．Methods: Selected 56 patients followed-up more than 6 months in our peritoneal dialysis center, exclude peritonitis, cancer, primary hypertension and taking statins of last 3 month. According to the peritoneal equilibration test(PET), the observed object were divided into high permeability group（D/P＞0.65）and low permeability group（D/P≤0.65）.And according to the PET, development of dialysis prescription, so that to achieve weekly clearance rate of the creatinine (Ccr)> 50L/W.1.73m2 and urea clearance index of KT/ V ≥ 1.7。Simultaneous determination of high-sensitivity C-reactive protein (Hs-CRP), serum creatinine (Scr),total cholesterol, high-density lipoprotein（HDL）, blood pressure(BP). Through ultrasound examination to determinate carotid intima-media thickness (IMT). Again determination of these serum markers and ultrasound examination 6 month after. Using the different value of the two measurements of IMT as the IMTV value. Using the average of two examination results of serum to analysis the relationship between IMTV and the other indicators. P <0.05 description difference was statistically significant. Result: ① The level of Hs-CRP , mean arterial pressure（MAP）and intima-media thickness variability（IMTV）in high permeability group of MPD patients were significantly higher than the low permeability group (P <0.05), HDL was significantly lower than the low permeability group (P <0.05).But no significant differences between the two groups of IMT（P＞0.05）② Pearson correlation analysis found that the IMTV in the peritoneal patients body's was a positive correlation with Hs-CRP, MAP and peritoneal permeability (D / P value) , negative correlation with HDL，no relationship with SBP,DBP and TCH . ③Multivariate logistic regression analysis found， the important influencing factors on IMTV were Hs-CRP levels and D / P value. Conclusion: ①High permeability group of inflammatory conditions is more serious than the low permeability group, this is the independent risk factors affecting the patients on intima-media thickness variability. ② Control the level of micro-inflammation especially for high permeability group is the important means of mitigate the level of IMTV, retard atherosclerosis and reduce the complications of cardiovascular events of MPD patients.

Key words: peritoneal transport characteristics, high-sensitivity C-reactive protein, carotid intima-media thickness, variability