Abstract: Objective To investigate the effects of high-flux hemodialysis on insulin resistance and cardiac function in non-diabetic patients maintained on hemodialysis.Methods Sixty patients with maintenance hemodialysis were selected,who had undergone hemodialysis for more than one year and were in a stable clinic status without signs of acute infections or other progressive diseases. These patients were divided into two groups.Patients in each group were treated using either Fx 60(high-flux dialyzer) or F7 HPS(low-flux dialyzer) for 6 months. Serum IL-6 and hsCRP were measured at the start and end of the study.Insulin resistance was assessed by using the homeostasis model assessment(HOMA-IR).The left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDd), left ventricular end-diastolic dimension(LVEDs),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT) and left ventricular ejection fraction(LVEF), left ventricular mass index(LVMI),ratio of E/A,the cardiac output(CO)were measured by ultrasonic cardiography at the start and end of the study. Results In patients with maintenance hemodialysis ,the average serum hsCRP、IL-6 and HOMA-IR were positively correlated with the values of LAD,LVEDd,LVEDs,IVST,LVPWT and LVMI（P <0.05）,but negatively correlated with the value of LVEF，E/A and CO（P <0.05）.After 6 month observation,the levels of HOMA-IR、IL-6 and hsCRP in high-flux group were significantly decreased according to HD group （P <0.05）. Conclusion This study demonstrates that high-flux dialyser provides a better effect on insulin resistance than does the low-flux dialyser for non-diabetic patients maintained on hemodialysis.

Key words: hemodialysis, High-flux dialyser, Insulin resistance