Abstract: Objectives: To investigate the level and variation of serum BMP-2, and how the eGFR, calcium-phosphate metabolism, inflammmation, lipids profile and nutrition index affact the production of BMP-2 in different phases of CKD. Methods: 154 patients with different phases of CKD were enrolled by a cross –section design. BMP-2 was measured by Elisa and clinical biochemistry parameters were evaluated at the same time . Results:The total of 154 patients come from 26 patients in CKD1, 22 in CKD2, 26 in CKD3, 20 in CKD4, 28 in pre-dialysis CKD5 and 32 patients who were undergoing maintenance hemodialysis. 28 healthy subjects was served as control. As a result: ① It demonstrated that the level of seru BMP-2 increased significantly in patients of CKD4, 5 and hemodialysis. ② The level of BMP-2 wassiginificant high in those patients such as，plasma phosphate > 1.62mmol/l or Ca × PO4 product > 55 mg2/dl2 ；serum albumin 3000 mg/l. ③BMP-2 level were positively correlated to serum phosphate, calcium phosphate product, CRP, BUN, creatinine and negatively correlated to seru albumin and glomerular filtration rate. Conclusions: The level of seru BMP-2 gradually increased in patients of advanced CKD and hemodialysis.The variation of BMP-2 is associated with renal function, calcium-phosphate metabolism, inflammation and albumin.

Key words: Bone morphogenetic protein 2, Chronic kidney disease, mineral metabolism