Abstract: High-volume hemofiltration is a kind of blood purification technology that developed on the basis of continuous renal replacement therapy.As a highly efficient nonspecific blood purification method HVHF has attracted more and more scholars and clinicians.Many clinical and experimental research demonstrate that, compared with the traditional continuous veno - venous hemofiltration , HVHF can better remove inflammatory medium, improve blood flow dynamics, reduce vascular active drug dosage, regulate immune disorders, and improve the survival rate. high volume hemofiltration concept, mechanism of action, clinical experiment research will be stated in this paper.