Abstract: Objective To analysis the relationship between dynamic changes of ischemia modified albumin (IMA) and major adverse cardiovascular events (MACE) in patients on peritoneal dialysis. Methods A total of 78 end stage renal disease patients on peritoneal dialysis over 3 months were enrolled. According IMA level, they were divided into high IMA group(IMA≥85.56KU/L) and normal IMA group(IMA<85.56KU/L). IMA level was repeated measurement in 6th month、12th month、18th month, 24th month after enrollment, and MACEs were recorded, non cardiovascular events survival were calculated. Results: There were 30 patients in high IMA group, and 19 cases suffered MACE during 24 months following-up. There were 48 patients in normal IMA group, and 6 cases suffered MACE during 24 months following-up（?2=21.91，P<0.001）. In high IMA group, IMA level measured in 18th months and 24th months were significantly higher than that measured when enrolled（96.69±18.18 KU/L vs 86.67±19.34 KU/L, t=2.28 P=0.03;98.03±18.56 KU/L vs 86.67±19.34 KU/L，t=2.56，P=0.01）. Non cardiovascular events survivals calculated in 6th month、12th month、18th month、 24th month were 0.77、0.60、0.43、0.37 in high IMA group. There were no significant changes of IMA level in normal IMA group. Survival analysis showed that there were significant difference between two groups in non-MACE survival（Log rank statistic ?2=22.66，P<0.001）. Conclusions: There is an increasing trend of IMA level in high IMA group, and MACE occurs gradually increased during following-up. IMA can be used as a good predictor of peritoneal dialysis patients with MACE.

Key words: ischemia modified albumin, peritoneal dialysis, major adverse cardiovascular events, dynamic change.