Abstract: A research of Macromolecules toxin removal and clinical efficacy of pruritus of hemodialysis combined with hemoperfusion on uremia patients HUANG Yong-zhang , XIAO Jie , XU Mi-qing . Department of Nephrology , The First Affiliated Hospital of Guangzhou Medical College ,Guangzhou 510120 , China Corresponding author：XU Mi-qing , Email: gyeyxu@163.com [ Abstract ] Objective To observe the effect of hemodialysis combined with hemoperfusion on uremic treatment effect. Methods 40 cases of maintenance hemodialysis (MHD) patients with uremia were randomly divided into hemodialysis ( HD ) group and hemodialysis combined with hemoperfusion ( HD+HP ) group. There were 20 cases in each group. Advanced glycation end products( AGEs ), homocysteine( Hcy ), parathyroid hormone( PTH ), β 2-Microglobulin( beta 2-MG ) of all patients were tested before and after the first treatment, before and after 12 weeks of treatment during serum. The efficacy of itching on MHD patients with uremia of both group were clinical observed. The correlation of changes of indexes and complications were analyzed. Results AGEs, Hcy, PTH,β 2-MG index in HD+HP group were lower than that of HD group after 12 treatments, P 0.05（0.867,0.054,0.727 in turn）. rs =0 ~ 1 between the reducing of PTH and β 2-MG and the remission of skin itching, P<0.05（0.045,0.037 in turn）. Conclusion HD+HP can effectively remove AGEs, Hcy, PTH and β 2-MG and remarkably release intractable pruritus in MHD patients. Level of blood PTH and β2-MG had positive correlation with uremic pruritus symptom.

Key words: [ keyword ] hemodialysis, hemoperfusion, uremia