Abstract: 【Abstract】Objective To evaluate the effect of blood lipid-regulating treatment on atherosclerosis in patients with maintenance hemodialysis.(MHD). Methods Sixty-three patients on maintenance hemodialysis in our dialysis center in Jan 1,2009-Jan 30,2010 were choiced in this study. Patients were divided into cntrol group and treatment group ,36 patients in treatment group were given lipid-lowering drugs for 3 years, Alll patients underwent a carotid artery examination. Intima-medial thickness ( IMT) of carotid arteries and the presence of atherosclerotic plaques were determined by the 3-9MHZ cobr Doppler ultrasonography(IU22). total cholesterol ( TC) , triglyceride(TG), high density lipoprotein cholesterol(HDLC), low density lipoprotein cholesterol(LDLC ) were determined as well. Results In the 3 years of follow-up, The average IMT were significantly increased in cntrol group patients (0.95±0.91 vs 1.37±0.89，P <0.05；0.95±0.91 vs 1.41±0.93，P <0.05；0.95±0.91 vs 1.57±0.99，P <0.01), and only in 3th year in treatment group patients(1.17±0.87 vs 1.50±0.55，P<0.05). The average IMT were significantly lower in patients with treatment group compare to cntrol group (1.18±0.75 vs 1.37±0.89， 1.13±0.78 vs 1.41±0.93 1.36±0.55 vs 1.57±0.99， P < 0. 01). The positive rate of atherosclerotic plaque were significantly lowered in patients with treatment groupcompare to cntrol group ( P < 0. 05), Carotid artery stenosis rate in patients with treatment group were significantly lower than in in patients with control group ( P < 0. 05). Conclusion The lipid lowering treatment can reduce the level of IMT ,decrease occurrence rate of atherosclerotic plaque and allivate The rate of carotid artery stenos in patients with maintenance hemodialysis.

Key words: 【Key Words】Arteriosclerosis, Maintenance hemodialysis, Blood lipid