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›› 2015, Vol. 14 ›› Issue (02): 0-0.
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Abstract: 【Abstract】 Objective:By comparing the treatment effectiveness of coupled plasma filtration adsorption (CPFA) and high volume hemofiltration(HVHF) in patients with severe sepsis,to investigate the advantages of CPFA.Methodology:Thirty-five patients with severe sepsis were randomly divided into CPFA group(n=18) and HVHF group(n=17).The patients received CPFA or HVHF on the basis of routine therapy.Changes of the body temperature,heart rate(HR),mean arterial pressure(MAP),the dose of dopamine,the oxygenation index(PaO2/FiO2),blood routine,biochemical parameters of liver and kidney function,the electrolytes,blood lactic acid,immune globulin,complement,APACHEⅡ score,TNF-α,IL-10,HMGB-1,CRP were compared between the 2 groups before and after the treatment for 10 hours.The safety of the two kinds of treatment were simultaneously evaluated.Results:After the two therapies,the body temperature,HR,serum creatinine(Scr),BUN,blood lactic acid,the dose of dopamine,APACHEⅡ score were all significantly decreasad,the MAP and PaO2/FiO2 were significantly increased,electrolytes and acid-base balance were well maintained,there were no statistical differences between the 2 groups(P>0.05).After the two kinds of treatment,no visible influences were found in the 2 groups in the levels of white blood cell count,hemoglobin count,platelet count,alanine transaminase,aspartate aminotransferase,bilirubin,serum albumin,immune globulin,complement(P>0.05).After the two therapies,the levels of TNF-α,IL-10,HMGB-1,CRP were all significantly decreased(P<0.05),however,these changes were more evident in CPFA group than in HVHF group(P<0.05).The two therapies were safe,and no therapy related adverse reactions such as haemorrhage,hypersensitiveness or embolism were noted during the two therapies.Conclusion:Although both CPFA and HVHF can safely and effectively adjust the internal environment of patients with severe sepsis,CPFA has better abilities in lowering levels of inflammation factors.
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https://www.cjbp.org.cn/EN/Y2015/V14/I02/0