Abstract: 【Abstract】Low transport bone disease, one of the most common types of bone disease in dialysis patients with end-stage renal disease, is characterized by low level of parathyroid hormone (PTH). The possible causes of low transport osteopathy include relative deficiency of PTH, iatrogenic factors, older age, diabetes mellitus, acidosis, etc. Studies have shown that PTH level is associated with the polymorphisms in vitamin D receptor (VDR) gene. VDR has four polymorphic loci, and BsmI polymorphism is related to PTH level in hemodialysis patients. "B" allele may be one of the causes of low PTH level in hemodialysis patients.

Key words: Low transport osteopathy, low parathyroid hormone, vitamin D receptor, gene polymorphism