Abstract: 【Abstract】The global incidence of chronic kidney disease (CKD) is as high as 8~16%. Anemia is one of the main complications in CKD patients. Factors causing renal anemia include erythropoietin deficiency, iron deficiency, blood loss, inflammation, vitamin D deficiency, hepcidin, secondary hyperparathyroidism and obesity, in which erythropoietin and iron deficiencies are the main causes for renal anemia. Therefore erythropoiesis stimulator and iron supplementation are two important therapies for renal anemia. Recent studies have found that hepcidin is closely related to renal anemia and is possibly related to iron state, inflammatory state and glomerular filtration rate. Hepcidin plays an important role in the regulation of functional iron deficiency. This article reviews the factors relating to hepcidin and renal anemia, and provides a basis for clinical treatment and study of renal anemia.

Key words: hepcidin, chronic kidney disease, anemia