Abstract: 【Abstract】The relationship between hyperuricemia (HUA) and chronic kidney disease (CKD) has been widely investigated. Current findings tend to conclude that hyperuricemia can be regarded as an“independent and modifiable”risk factor for the deterioration of renal disease. However, the cause-effect relationship cannot be confirmed to date. Many researchers have focused on this issue. This review elaborates the links between HUA and CKD in a rather novel and comprehensive perspective, seeking to retard the progression of CKD by control of uric acid.

Key words: Hyperuricemia, Mechanism, Chronic kidney disease, Vascular calcification