Abstract: 【Abstract】Objective To study the application of low calcium dialysate (1.25 mmol/L) in maintenance hemodialysis (MHD) patients and survey its clinical effects on serum calcium (Ca), phosphate (P) and intact parathyroid hormone (iPTH). Methods By search of publications in the last 10 years in CNKI, Wanfang China Science Periodical Database (CSPD), VIP China Science and Technology Journal Database (CSTJ), SinoMed database and PubMed database, a meta-analysis was performed using the publications about the clinical application of low calcium dialysate in MHD patients, and the levels of serum calcium, phosphate and iPTH were then compared between MHD patients using low calcium dialysate (LCD) and calcium 1.5 mmol/L dialysate (HCD). Results Eleven publications were included in the meta-analysis. Serum Ca level in patients using LCD was lower than that in those using HCD (SMD=-0.679, 95% CI -1.157～-0.202, P=0.005). Serum P had no significantly difference between patients using LCD and those using HCD (SMD=-0.824,
95% CI -1.733～0.085, P=0.076). iPTH level was significant higher in patients using LCD than in those using HCD (SMD=1.235, 95% CI 0.555～1.915, P＜0.001). Conclusion LCD can decrease the levels of serum Ca and P and increase the level of iPTH, while HCD can increase the level of serum Ca, decrease the level of serum P, and have no significant effect on iPTH. These two kinds of dialysate have similar effect on the decrease of serum P.

Key words: low calcium dialysates, serum calcium, serum phosphate, iPTH, meta-analysis