Abstract: 【Abstract】Objective To analyze the influence factors on the effect of plasma exchange (PE) in the treatment of patients with acute Guillain- Barré syndrome (GBS). Methods A total of 118 acute GBS patients were divided into PE group and non- PE group. Therapeutic effect was compared between the two groups and the influence factors affecting the PE effect were investigated. Results Fifty GBS patients in PE group were responsive to PE with the effective rate of 73.5%, while 27 GBS patients in non-PE group were responsive with the effective rate of 54% (P=0.023). Multivariate analyses revealed that the number of PE (odds ratio 2.123) and axonal damage (odds ratio 4.758) were the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Conclusion PE is an effective treatment for acute GBS. The number of PE and the axonal damage are the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Further study is required to validate the findings of this study.

Key words: guillain-Barré, syndrome, plasma exchange, therapeutic effect, influence factors.