Abstract: 【Abstract】Objective To explore the effect of regular exercise guided by cross- theoretical model (CTM) on quality of life in maintenance hemodialysis (MHD) patients. Methods Sixty-two MHD patients were randomly divided into experimental group and control group. The control group was given routine exercise health guidance, and the experimental group was given the CTM-based health guidance. Regular exercise, physical fitness, hemoglobin, serum albumin and other indicators as well as SF-36 score of health status survey at baseline and after the treatment for 6 months were recorded. Results Regular exercise
had no statistical difference at baseline status between the two groups (t=0.069, P=0.793), but became different after the treatment (t=5.391, P=0.002). The improvement of normal walking speed, maximum stride speed, hemoglobin and serum albumin were statistically significant (t=2.021, 2.870, 3.741 and 4.587 respectively; P=0.046, 0.006, 0.024 and 0.018 respectively). The scores of overall health, mental health, emotional function, social function, energy, body pain, physiological function, physiological function in the SF-36 survey were statistically different (t=3.698, 4.325, 10.362, 2.946, 3.498, 4.264, 3.026 and
4.125 respectively; P=0.025, 0.019, ＜0.001, 0.045, 0.027, 0.012, 0.031 and 0.015 respectively). Conclusion Health guidance based on CTM can improve the quality of life of MHD patients, which is worthwhile to be used in clinical practice.

Key words: hemodialysis, movement, cross-theoretical model, quality of life