Abstract: 【Abstract】Objective The prevalence and risk factors for chronic kidney disease (CKD) among firstgrade relatives and spouses of maintenance dialysis (MD) patients were investigated. Methods The subjects were divided into three groups: first-degree relative group (124 cases), spouse group (95 cases) and
control group (823 cases). Clinical characteristics and prevalence of CKD in the three groups were compared, and the risk factors were analyzed. Results The proportion of CKD in the first- degree relative group and spouse group was higher than that in the control group (23.4% vs. 16.2%, χ2=3.894, P=0.049;
30.5% vs. 16.2%, χ2=11.916, P＜0.001). Multiple logistic regression analysis for the risk factors for CKD in all participants found that the risk factor for CKD in first-degree relatives was 1.86 times higher than that in non first- degree relatives (OR=1.86, 95% CI: 1.12～3.11, P=0.004), the risk factor for CKD in spouses was 2.16 times higher than that in non-spouses (OR=2.16, 95% CI: 1.27～3.67, P=0.018), and older age, diabetes and hypertension were the independent risk factors for 2%, 21% and 112% increases of CKD risk respectively (OR=1.02, 95% CI: 1.01～1.03, P=0.005 for older age; OR=1.21, 95% CI: 1.11～1.31, P＜0.001 for diabetes; OR=2.12, 95% CI : 1.49～3.03, P＜0.001 for hypertension). Conclusion First-degree relatives and spouses of MD patients are at higher risk for CKD. Diabetes, hypertension and older age are the risk factors for CKD.

Key words: chronic kidney disease , maintenance dialysis, first degree relative, spouse, risk factor