【Abstract】Objective To understand the electronic health literacy in maintenance hemodialysis (MHD) patients and to explore its correlation with quality of life. Method A total of 188 MHD patients were enrolled. General information questionnaire, electronic health literacy scale (e-HEALS) and quality of life scale (SF-36) were used in this study. Result The score of electronic health literacy was low (23.4±5.3) in these patients. The scores of physiological function, physiological function and social function were higher in patients with higher e-HEALS (the score ＞32) than in those with lower e-HEALS (t=2.171, 4.238 and 4.341 respectively; P=0.042, 0.001 and 0.013 respectively). Conclusion The level of electronic health literacy was lower in MHD patients. The increase of electronic health literacy in MHD patients can improve their quality of life.