【Abstract】Objectives To investigate the incidence of pruritus and its influencing factors in patients with peritoneal dialysis (PD). Methods According to the improved DUO scoring method, the pruritus questionnaire survey was conducted among PD patients who were regularly followed up in the PD Center of Peking University People's Hospital. Clinical data and laboratory results were collected. Logistic regression was used to analyze the influencing factors for pruritus, and multivariate linear regression was used to analyze the influencing factors for the severity of pruritus. Results ①A total of 123 PD patients were enrolled in this study, including 53 males (43.1%) with an average age of 60.15±12.46 years and a dialysis duration of 37.14±27.79 months. The main primary disease was diabetic nephropathy (35.8%). ②Eight-two PD patients had skin pruritus,

with an incidence of 66.7% . Logistic regression analysis showed that dry skin (OR=4.956, 95% CI 2.364～10.388, P<0.001), high serum CRP (OR=1.251, 95% CI 1.075～1.456, P=0.005), high serum phosphorus (OR=5.029, 95% CI 1.030～24.560, P=0.046) and high serum magnesium (OR=3.533, 95% CI 0.390～6.124, P=0.023) were the independent risk factors for pruritus in PD patients. ③Of the 82 patients with pruritus, 40.2% had mild pruritus, 46.3% had moderate pruritus, and 13.4% had severe pruritus. Multivariate linear regression analysis showed that dry skin (β =0.674, P＜0.001), serum phosphorus (β =0.631, P=0.004) and serum iPTH level (β=0.001, P=0.040) were the independent risk factors for the severity of pruritus in PD patients. Conclusions The incidence of skin pruritus is higher in PD patients. PD patients with dry skin, higher serum levels of CRP, magnesium and phosphorus are more likely to suffer from pruritus. PD patients with dry skin, higher serum levels of phosphorus and iPTH had more severe pruritus.