Chinese Journal of Blood Purification ›› 2019, Vol. 18 ›› Issue (11): 766-768.doi: 10.3969/j.issn.1671-4091.2019.11.009

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Research progress in sclerostin in the pathogenesis of renal osteodystrophy

  

  1. 1Graduate School of Hebei Medical University, Shijiazhuang 050000, China;  2Department of Nephrology, Tangshan Workers Hospital Affiliated to Hebei Medical University, Tangshan 063000, China
  • Received:2019-04-12 Revised:2019-06-27 Online:2019-11-12 Published:2019-10-28

Abstract: 【Abstract】Renal osteodystrophy is one of the common and serious complications in CKD patients, leading to a significant increase in fracture risk and morbidity and seriously affecting the quality of life. Sclerostin is a glycoprotein expressed by bone cells, affects bone growth and metabolism at all stages, and participates in the pathogenesis of renal osteodystrophy. This review introduces the advances in the study of sclerostin in renal osteodystrophy.

Key words: Chronic kidney disease, Renal osteodystrophy, Sclerostin

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