Abstract: 【Abstract】Organ donation serves as the fundamental approach for treatment of the patients with endstage organ failure, and the success rate relies heavily on the quality of donor maintenance. Severe traumatic
brain injury is a primary source of donors, but is often complicated with severe internal environment disturbances, hemodynamic collapse, and multiple organ dysfunction syndrome (MODS). Blood purification technology is an important procedure for critical care. Among these techniques, continuous blood purification
(CBP) has emerged as a key intervention for donor maintenance, by clearing inflammatory mediators, stabilizing internal environment and hemodynamics, and providing renal support. This article systematically reviews the esential value of CBP in donor maintenance, including regulating internal environment (e.g., correcting hypernatremia), maintaining circulatory stability, implementing renal replacement therapy, and removing inflammatory mediators and toxins. This review also provides the values and evidences in protecting target organs (heart, lungs and kidneys) and managing special donors (e.g., those with poisoning or heat stroke). Current studies have confirmed the clinical benefits of CBP. However, high-quality evidence-based medical evidence (such as randomized controlled trial) is insufficient, especially in mode optimization, standardized protocols, and long-term outcome evaluation. Future research is needed to refine the strategies and to improve the survival rate of transplanted organs.

Key words: Organ donation, Donor management, Blood purification