Abstract: Therapeutic plasma exchange (TPE) has been proven effective for various diseases, but some conditions may require concurrent continuous renal replacement therapy (CRRT). The TPE-CRRT combination technique enables both forms of extracorporeal blood purification to be performed simultaneously. However, the feasibility, safety, therapeutic efficacy, and application prospects of the TPE-CRRT combination technique remain unclear. In light of this, our team reviewed the literature, introduced the forms of TPE, summarized the forms of TPE combined with CRRT, and outlined advantages and disadvantages of the combined therapy, as well as our clinical experience, to facilitate future research on combined therapy.

Key words: Therapeutic plasma exchange, Continuous renal replacement therapy, Tandem