Abstract: Objective To investigate the effect of statin therapy on microinflammation in the patients with uremia. Methods Fifty-five uremic patients were randomly divided into control patient groups (CPG,n=27) and statin therapy group( STG,n=28),20 healthy people as the normal control group(NCG,n=20). The concentrations of serum C-reactive protein (CRP), interleukin-1(IL-1), interleukin-6 (IL-6) and tumor necrosis factor-a(TNF-a) were detected by radioimmunoassay. Results Compared with the NCG, the concentrations of CRP, IL-1, IL-6 and TNF-a in pateints of CPG and STG before statin treatment were much higher than these in NCG, and meanwhile the concentrations of plasma albumin, proalbumin and hemoglobin in patients of CPG and STG were significantly lower than those in NCG. The concentrations of total cholesterol(TC), triglyceride low density lipoprotein-cholesterol (LDL-C) and serum glucose had no difference between CPG and STG. The concentrations of CRP, IL-1, IL-6 and TNF-a decreased markedly,and the concentrations of plasma albumin, proalbumin and hemoglobin increased significantly in pateints of STG after being treated with fluvastatin (20mg/d) for 4 months, and the concentrations of creatinine and urea nitrogen also decreased slightly. Conclusion The microinflammation in patients with uremia could be inhibited effectively by statin treatment.

Key words: Microinflammation, Statin