中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (03): 145-148.doi: 10.3969/j.issn.1671-4091.2022.03.001

• 专题与讲座 •    下一篇

阻塞性睡眠呼吸暂停与慢性肾脏病

程利男1, 陈育青1   

  1. 1北京大学第一医院肾内科；北京大学肾脏疾病研究所；卫生部肾脏疾病重点实验室；
    慢性肾脏病防治教育部重点实验室（北京大学）；中国医学科学院免疫介导肾病诊治创新单元
  • 收稿日期:2021-11-08 修回日期:2021-12-02 出版日期:2022-03-12 发布日期:2022-03-16
  • 通讯作者: 陈育青 cyq@bjmu.edu.cn E-mail:cyq@bjmu.edu.cn

Obstructive sleep apnea and chronic kidney disease

  1.  1Renal Division Peking University First hospital, Institute of Nephrology Peking University, Key Laboratory of Renal Disease
    Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment Ministry of Education of China, Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Disease Chinese Academy of Meidcal Sciences, Beijing 100034, China.
  • Received:2021-11-08 Revised:2021-12-02 Online:2022-03-12 Published:2022-03-16
  • Contact: Yuqing Chen E-mail:cyq@bjmu.edu.cn

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摘要： 【摘要】慢性肾脏病患病率逐年攀升，且其合并心血管疾病和死亡风险的增加，造成沉重的社会疾病经济负担。阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)不仅是慢性肾脏病(chronic kidney disease, CKD)发生及进展的独立危险因素，而且在慢性肾脏病患者中发生率较高。近年来，越来越多的研究表明OSA 与CKD 之间存在双向关系。因此，认识两者之间的关系并早期加以干预有助于缓解OSA 症状，延缓CKD 进展，提升生活质量。本文主要综述OSA 与CKD 之间的联系，包括了流行病学、发病机制及治疗策略。

关键词: 阻塞性睡眠呼吸暂停, 慢性肾脏病

Abstract: 【Abstract】Obstructive sleep apnea (OSA) is regarded as an independent risk factor for chronic kidney disease and is highly prevalent among patients with chronic kidney disease (CKD). In recent years, increasing evidence has demonstrated a bidirectional relationship between obstructive sleep apnea and chronic kidney disease. Therefore, a comprehensive understanding of the relationship and early intervention could alleviate symptoms of OSA and potentially prevent or delay CKD progression, which ultimately allows for improvement of quality of life. This review mainly focuses on the bidirectional relationship between OSA and CKD, including the epidemiology, pathogenesis, and treatment strategies.

Key words: Obstructive sleep apnea, Chronic kidney disease

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