Abstract: Objective To investigate the clinical effects of continuous renal replacement therapy (CRRT) for the treatment of patients with early hepatic dysfunction induced by sepsis. Methods A total of 287 cases with liver dysfunction after severe pulmonary infection and sepsis and treated in the ICU of First People's Hospital of Yangjiang city from Jan. 2013 to Dec. 2016 were recruited. The patients were randomly divided into CRRT group (n=156) and control group (routine treatment group, n=131). Blood samples were collected at the 1st, 3rd and 7th day in the early morning after the presence of hepatic dysfunction for the measurement of alanine aminotransfease (ALT), aspartate aminotransferase (AST), serum total bilirubin (STB), albumin (ALB) and prothrombin time (PT). Laboratory parameters were used for statistical analyses. Results After the treatment for 3 days, changes of AST (F=8.705, P=0.014) and STB (F=9.016, P=0.009) were statistically significant (P＜0.05) in CRRT group as compared with those in control group, but ALB, ALT and PT had no statistical differences (P＞0.05). After the treatment for 7 days, changes of ALT (F=8.413, P=0.016), AST (F=7.812, P=0.023) and STB (F=9.413, P=0.005) were statistically significant (P＜0.05) as compared with those in control group, but ALB and PT had no statistical differences (P＞0.05). Conclusion CRRT can improve the patients with early liver dysfunction induced by sepsis.

Key words: CRRT, Sepsis, Hepatic Dysfunction, ALT, AST