Abstract: 【Abstract】Objective To investigate the relationship between baseline serum uric acid level and primary peritoneal dialysis-associated peritonitis. Methods Peritoneal dialysis (PD) patients admitted to the Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University for the first time between January 2012 and January 2018 and followed up regularly for a long period of time were recruited in this study. Patients were divided into primary peritonitis group and non- peritonitis group. The relationship between baseline serum uric acid level and other related laboratory indexes was analyzed in the two groups. The
level of baseline serum uric acid for the prediction of primary PD-associated peritonitis was evaluated. Results Primary peritonitis occurred in 37.3% of the 130 PD patients. Patients in primary peritonitis group had younger age (t=1.664, P=0.020), higher levels of baseline serum uric acid (t=-6.367, P<0.001) and phosphorus (t=-3.691, P<0.001) and lower hemoglobin (t=2.388, P=0.018), as compared with those in non-peritonitis group. Primary PD- associated peritonitis was positively correlated with baseline levels of serum uric acid(r=0.487, P<0.001) and serum phosphorus (r=0.310, P<0.001), and negatively correlated with hemoglobin(r=-0.206, P=0.018). Univariate regression analysis showed that higher baseline serum uric acid (OR=1.013,
95% CI=1.007~1.018, P<0.001) and lower HGB (OR=0.968, 95% CI=0.938~1.000, P=0.047) were the risk factors for primary PD-associated peritonitis. Multivariate analysis showed that higher baseline serum uric acid (OR=1.014, 95% CI=1.008~ 1.019, P<0.001) lower albumin (OR=0.909, 95% CI= 0.840~0.985, P=0.020) and diabetes (OR=3.808, 95% CI=1.180~ 12.288, P=0.006) were the risk factors for primary PD-associated peritonitis. Conclusions Baseline serum uric acid level was significantly correlated with primary PD-associated peritonitis in continuous PD patients. For end-stage renal disease patients treated with PD, higher baseline serum uric acid level before PD catheterization will be more likely to complicate with primary PD-associated peritonitis.

Key words: Infection, Uric acid, Peritoneal dialysis, Peritoneal dialysis-associated peritonitis