Abstract: 【Abstract】Objective To analyze the correlation between interdialytic weight gain and intradialytic hypotension (IDH). Methods A total of 146 patients with maintenance hemodialysis (MHD) admitted to Daxing Teaching Hospital of Capital Medical University from January 2017 to June 2018 were enrolled in this study. All patients underwent regular bicarbonate dialysis (3 times/week). Their baseline data, blood biochemistry, body mass before and after dialysis, and blood pressure before and after dialysis were collected. According to the presence or absence of IDH during dialysis, the patients were divided into IDH group (53 cases) and non-IDH group (93 cases). The analysis of related factors affecting IDH was performed. The correlation between interdialytic weight gain (IDWG), IDWG% and blood pressure reduction before and after dialysis was analyzed. Results Age, prevalence of diabetes, IDWG, IDWG%, systolic blood pressure (SBP) before dialysis, mean arterial pressure (MAP) before dialysis, ultrafiltration volume and ultrafiltration rate in IDH group were higher than those in non-IDH group (t or χ2=6.413, 12.23, 6.821, 6.561, 3.123, 10.059 and 9.717 respectively; P＜0.001). Albumin before dialysis in IDH group was lower than that in non- IDH group (t=3.852, P＜0.001). Age (OR=2.186, 95% CI: 1.329～3.596, P=0.002), SBP before dialysis (OR=2.232, 95% CI:1.338～3.723, P=0.002), IDWG (OR=2.815, 95% CI:1.557～5.088, P=0.001), IDWG% (OR=3.093, 95% CI: 1.671~5.723, P＜0.001), ultrafiltration volume (OR=2.109, 95% CI: 1.216～3.657, P=0.008) and ultrafiltration rate (OR=2.284, 95% CI: 1.375～3.795, P=0.002) were the independent risk factors for IDH during dialysis in MHD patients. IDWG and IDWG% were positively correlated with the reductions of SBP (r=0.372 and 0.379; P＜0.001), DBP (r=0.381 and 0.395; P＜0.001) and MAP (r=0.314 and 0.305; P=0.002 and 0.003) before and after dialysis. The risk of IDH in patients with IDWG% ≥4.1% was higher than that in patients with IDWG% ＜4.1% (log rank test=21.670, P＜0.001). Conclusion There are many factors affecting the occurrence of IDH during dialysis in MHD patients. Interdialytic weight gain is related to the occurrence of IDH. It is necessary to strictly control the interdialytic weight gain.

Key words: Maintenance hemodialysis, Body mass growth, Intradialytic hypotension, Risk factor