Abstract: 【Abstract】Objective To analyze laboratory indexes and clinical characteristics of the patients dropped out of peritoneal dialysis (PD) at different dialysis age before rEentering PD, and to evaluate the influencing factors for PD, so as to choose an appropriate way of dialysis and to improve the quality of life of these patients. Methods We retrospectively analyzed the clinical data of 262 PD patients who dropped out of PD in the Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University from January 2009 to December 2019. They were treated with 2000 ml Baxter 1.5% or 2.5% peritoneal dialysate at least three times a day. They were divided into three groups according to the dialysis age: group A, dialysis age ≤1 year (n=96); group B, dialysis age >1 year and <3 years (n=100); and group C, dialysis age ≥3 years (n=66). Their laboratory indexes and clinical characteristics before rEentering PD were compared. Results Compare with those in group C, patients in group A had lower plasma albumin and total protein, lower proportion of female(t, Z and χ2=9.204, -2.503 and 3.905 respectively; P=0.002, 0.013 and 0.048 respectively), and higher prevalence of cardiovascular complications (palpitation and chest tightness after exercise) (29.17% vs. 6.06%, χ2=13.311, P=0.001) and digestive system complications (nausea, constipation, diarrhea) (41.67% vs. 13.64%, χ2= 15.567%, P=0.001). Multivariate logistic regression analysis showed that plasma albumin level was the independent risk factor for early PD withdrawal(OR:1.106,95% CI:1.004～1.217，P=0.040). In addition, linear correlation analysis showed that plasma albumin and dialysis age were positively correlated (r=0.153, P=0.015). Conclusion Male patients, and patients with poor nutritional status before dialysis and apparent cardiovascular and digestive system complications were more likely to drop out of PD earlier. Hemodialysis may be suitable for them. Plasma albumin level was an independent risk factor for early withdrawal of PD.

Key words: Peritoneal dialysis, Dropout, Uremia