Abstract: 【Abstract】Objective To assess the effect of high flux hemodialysis (HFHD) and low flux heamodialysis (LFHD) on end-stage renal disease (ESRD) patients by Meta analysis. Methods The randomized controlled trails (RCTs) and quasi-RCTs which compared HFHD with LFHD in ESRD patients were searched in the PubMed, Embase, Cochrane Library, CNKI and Wanfang electronic databases. RevMan5.3 was used for meta analysis. Results A total of 22 studies were included that involved 7,590 participants with ESRD. Meta analysis results showed that all-cause mortality was lower in the participants using HFHD than in those using LFHD (RR= 0.766, 95% CI: 0.659～0.890, P<0.001). Compared with the LFHD group, the HFHD group showed better outcomes in cardiovascular mortality (RR=0.792, 95% CI: 0.696～0.901, P<0.001), beta-2 microglobulin (MD=-10.235, 95% CI: -12.475～ -7.994, P<0.001), lipid profiles (total cholesterol: MD=-0.244, 95% CI: -0.446～- 0.041, P=0.020; triglycerides: MD=- 0.248, 95% CI: - 0.406～- 0.090, P=0.002) and inflammation markers (SMD=-0.225, 95% CI: -0.340～-0.110, P<0.001). Conclusion Compared the patients using LFHD, ESRD patients using HFHD had lower mortality and cardiovascular mortality with better clearance effects for lipids, middle molecular substances and inflammation factors, bringing more benefits to ESRD patients.

Key words: High flux hemodialysis, Low flux hemodialysis, End- stage renal disease, Mortality, Meta analysis