Abstract: Objective  To investigate the effect of blood pressure variability on the function of arteriovenous graft (AVG) in hemodialysis patients.  Methods A retrospective study was conducted to collect patients who used AVG as vascular access in December 2020. Blood pressure variability during hemodialysis for 4 consecutive weeks (12 times in total) was analyzed, and the patients were divided into control group (blood pressure variability >17.3, n=40) and observation group (blood pressure variability ≤17.3, n=40) according to the median blood pressure variability. The incidence of thrombosis and auxiliary primary patency rate were observed to explore their correlation.  Results  A total of 80 patients were included, and the clinical data within one year were observed. The AVG thrombosis rates in the control group and the observation group were 77.5% (31/40) and 22.5% (9/40), respectively, and the difference between the two groups was statistically significant (χ²=24.200, P<0.001). The 12-month auxiliary primary patency rate in the control group was lower than that in the observation group (Log-rank, χ²=63.870, P＜0.001).  Conclusion  The author believes that the higher the blood pressure variability, the greater the hemodynamic changes, and the higher the risk of thrombosis in AVG. It is recommended to evaluate blood pressure variability in dialysis regularly, and take targeted intervention measures to reduce thrombosis in AVG and improve the auxiliary primary patency rate.

Key words: Hemodialysis, Graft arteriovenous fistula, Blood pressure variability, Thrombosis, Auxiliary primary patency