Chinese Journal of Blood Purification

12 August 2024, Volume 23 Issue 08 Previous Issue    Next Issue

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Expert consensus on management of chronic kidney disease associated cardiomyopathy Work group of expert consensus on management of chronic kidney disease associated cardiomyopathy 2024, 23 (08):  561-580.  doi: 10.3969/j.issn.1671-4091.2024.08.001 Abstract ( 520 )   PDF (1043KB) ( 154 )   The incidence of chronic kidney disease (CKD) associated cardiomyopathy is high, which seriously affects the prognosis of patients. The comprehensive management of such patients is a challenge for both nephrologists and cardiologists. Based on the current status of diagnosis and treatment, this expert consensus is jointly written by an expert consensus writing committee composed of experts in nephrology, cardiology, pharmacy and radiology. Based on evidence-based medicine and clinical experience, this consensus systematically introduces the definition, risk factors, pathogenesis, diagnosis, screening, comprehensive management (lifestyle, blood pressure, anemia, chronic kidney disease-mineral and bone disorder, renal replacement therapy) and prevention of CKD associated cardiomyopathy. The purpose of this expert consensus is to guide and standardize the management of CKD associated cardiomyopathy, and to improve the understanding and clinical diagnosis and treatment. Metrics

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Diagnostic value of serum sclerostin and BALP combined detection for osteoporosis in patients on peritoneal dialysis CAO Qian-ying, SHI Ya-nan, YANG Fan, ZHOU Jing-jing , YUAN Dan , LI Zhong-xin 2024, 23 (08):  581-585.  doi: 10.3969/j.issn.1671-4091.2024.08.002 Abstract ( 94 )   PDF (571KB) ( 17 )   Objective To explore the diagnostic value of serum Sclerostin and BALP in the diagnosis of osteoporosis in patients with peritoneal dialysis (PD).  Methods A total of 136 patients who were followed up in PD outpatient Department of Beijing Luhe Hospital affiliated to Capital Medical University from January 1 to 20, 2023 were selected as the study objects. Bone mineral density (BMD) T and Z values of proximal femur were measured in all enrolled patients, and the patients were divided into normal bone group and osteoporosis group according to the BMD values. Meanwhile, the general data, biochemistry, IPTH, Sclerostin and bone-specific alkaline phosphatase (BALP) were collected. The clinical data, biochemical indexes, serum Sclerostin and BALP levels were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of osteoporosis in PD patients. Receiver operating characteristic (ROC) curve was drawn, and the area under ROC curve (AUC) was used to evaluate the diagnostic value of serum Sclerostin, BALP and their combined detection on osteoporosis in PD patients. Results  ①Among the 136 PD patients included in the study, 62 were males, with a median age of 58.00 (49.25, 65.00) and a median dialysis age of 36.00 (25.00, 49.75) months, 71 were osteoporosis patients (52.20%), 74 were diabetic patients (54.41%), and 64 were hypertensive patients (47.06%). There were significant differences in age (Z=-3.273, P=0.001), dialysis age (Z=-4.359, P<0.001) and diabetes mellitus (χ2=25.520, P<0.001) between the normal bone group (n=65) and the osteoporosis group (n=71). ②The results of multivariate Logistic regression analysis showed that age (OR=1.065, 95% CI, 1.005，1.128, P=0.034), dialysis duration (OR=1.042, 95% CI, 1.006～1.078, P=0.020), diabetes (OR=3.607,95% CI,1.217～10.687，P=0.021), Sclerostin (OR=1.012, 95% CI, 1.006～1.019，P＜0.001) and BALP (OR=1.212, 95% CI, 1.095～1.342, P＜0.001) were all risk factors affecting the occurrence of osteoporosis in PD patients (P<0.05). ③ROC curve analysis showed that the sensitivity of serum Sclerostin, BALP and their combination for the diagnosis of osteoporosis in peritoneal dialysis patients were 71.8%, 64.8% and 81.7%, and the specificity was 76.9%, 84.6% and 93.8%, respectively. The AUC was 0.817, 0.789 and 0.902, and the Jorden index was 0.494, 0.488 and 0.755, respectively.  Conclusion   Serum Sclerostin and BALP levels are independent risk factors for osteoporosis in PD patients, and the combined detection of serum Sclerostin and BALP is more effective in the diagnosis of osteoporosis in peritoneal dialysis patients. Metrics

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The impact of lactate on circuit clotting in regional citrate anticoagulation continuous renal replacement therapy DUAN Peng-cheng, LU Mu-rong, YU Ting-ting, ZHOU Li-zhen, WANG Shuang-shuang, CHEN Wei-yan, YU Hong-jing 2024, 23 (08):  586-589,595.  doi: 10.3969/j.issn.1671-4091.2024.08.003 Abstract ( 84 )   PDF (556KB) ( 24 )   Objective  This retrospective study aimed to identify factors contributing to clotting within 48 hours in circuits of continuous renal replacement therapy (CRRT) using regional citrate anticoagulation (RCA). Methods  Data from the intensive care unit of the Second Affiliated Hospital of Guangzhou Medical University between June 2021 and July 2023 were analyzed. Circuits were categorized into clotting and non-clotting groups based on 48-hour clotting occurrence. COX regression analysis was performed to identify clotting risk factors. Results A total of 114 patients with 179 sets of CRRT circuits and corresponding data were included in the study. Among them, clotting within 48 hours of initiation was observed in 105 cases, while 74 cases did not experience clotting within 48 hours. Venous pressure (HR=1.008, 95% CI: 1.0～1.016, P=0.045)and lactate level ≥2 mmol/L (HR=1.517, 95% CI：1.009～2.280, P=0.045) were identified as independent risk factors for circuit clotting within 48 hours of CRRT. On the other hand, citrate dose ≥3.2 mmol/L (HR=0.461, 95% CI：0.312～0.682, P＜0.001) was identified as a protective factor. Conclusion  In continuous renal replacement therapy using regional citrate anticoagulation, high venous pressure, increased platelet count, and elevated lactate levels were associated with increased clotting risk within 48 hours. Pre-filling circuits adequately and optimizing catheter positioning before CRRT initiation are recommended. Managing patients with high lactate levels and impaired tissue perfusion through fluid resuscitation can reduce clotting risk. Metrics

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Correlation between red blood cell distribution width to albumin ratio and all-cause mortality in maintenance hemodialysis patients ZHANG Shao-qing, LYU Yu-feng, DONG Hai-xia 2024, 23 (08):  590-595.  doi: 10.3969/j.issn.1671-4091.2024.08.004 Abstract ( 94 )   PDF (599KB) ( 8 )   Objective  To explore the correlation between red blood cell distribution width to albumin ratio (RAR) and all-cause mortality in maintenance hemodialysis (MHD) patients.  Methods  A total of 100 MHD patients who met the inclusion criteria were recruited, and 24 patients died and 76 survived at the study endpoint. Their baseline clinical data and laboratory indicators were collected and compared between the death group and the survival group.  The correlation between RAR and all-cause mortality in the MHD patients was analyzed.  Results  Patients in the death group were older than those in the survival group (Z=        -4.086, P＜0.001). The proportion of patients with diabetes, neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), RAR and C-reactive protein (CRP) were higher in the death group than in the survival group (χ²/Z=5.099, -2.215, -2.163, -2.797 and -2.680 respectively; P=0.024, 0.027, 0.031, 0.005 and 0.007 respectively). Serum HDL-C was lower in the death group than in the survival group (Z=-2.741, P=0.006). Multivariate Cox regression analysis suggested that age (HR=1.073, 95% CI:1.030～1.118, P=0.001), diabetes (HR=8.197, 95% CI:2.911～23.082, P＜0.001), RAR (HR=33.179, 95% CI:1.588～693.181, P=0.024) and CRP (HR=1.178, 95% CI:1.059～1.310, P=0.002) were the risk factors for all-cause mortality. The overall survival rate was lower in the patients with higher RAR than in those with lower RAR (χ2=20.341, P＜0.001). ROC curves using RAR, CRP and combination of RAR and CRP to predict all-cause mortality in MHD patients showed that the area under curves were 0.690 (95% CI:0.582～0.798, P=0.005), 0.682 (95% CI:0.560～0.804, P=0.007) and 0.738 (95% CI:0.633～0.843, P＜0.001) respectively.   Conclusion  RAR is correlated with all-cause mortality in MHD patients. The combination of RAR and CRP will have better predictive value for all-cause mortality in MHD patients. Metrics

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Clinical study of Dusp6 in peripheral blood to predict all-cause death and cardiovascular event death in maintenance peritoneal dialysis patients GUO Bao-zhu, LIU Jun-fen, HAN Xiao-li, LI Ya-qi, TIAN Xiao-min, JIN Xin, WEI Zhi-feng, LIU Sheng-jun 2024, 23 (08):  596-600.  doi: 10.3969/j.issn.1671-4091.2024.08.005 Abstract ( 77 )   PDF (490KB) ( 8 )   Objective  To investigate dual-specificity phosphatase 6 (Dusp6) in peripheral blood combined with clinical parameters to predict all-cause death and cardiovascular event death in maintenance peritoneal dialysis (PD) patients.  Methods  Patients who underwent PD catheterization and maintenance PD were selected for the single-center and prospective cohort study. Dusp6 in peripheral blood was measured. Baseline clinical data, all-cause death and cardiovascular event death were collected. Kaplan-Meier method was used to compare the mortality of PD patients with different levels of Dusp6. Cox regression model was used to analyze the influencing factors for all-cause death and cardiovascular event death. ROC curve was used to evaluate the predictive indicators for all-cause death and cardiovascular event death.   Results  A total of 138 PD patients were included and followed up for 19 (15, 23) month. There were 48 all-cause death cases (34.78%) and 26 cardiovascular death cases (18.84%). The median level of Dusp6 in peripheral blood was 38.9pg/ml. The all-cause mortality and cardiovascular event mortality in patients with peripheral blood Dusp6 ≥38.9pg/ml were higher than in those with Dusp6 ＜38.9 pg/ml (χ²=17.5, P＜0.001; χ²=10.56, P=0.001). Age, low density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP) and Dusp6 were the influencing factors for all-cause death (HR=1.104, 3.105, 21.929 and 1.075 respectively; 95% CI:1.021～1.193, 1.069～9.013, 6.280～76.575 and 1.008～1.147 respectively; P=0.013, 0.037, ＜0.001 and 0.028 respectively); when combined the 4 influencing factors to predict all-cause death, the sensitivity and specificity were 81.11% and 80.17% respectively. Age, uric acid, CRP and Dusp6 were the influencing factors for cardiovascular event death; when combined the 4 influencing factors to predict cardiovascular event death, the sensitivity and specificity were 81.25% and 80.77% respectively.  Conclusion  The high expression of Dusp6 in peripheral blood is associated with all-cause death and cardiovascular event death in PD patients. The combination of Dusp6 and other related clinical parameters has better predictive values for all-cause death and cardiovascular event death in PD patients. Metrics

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Diagnostic value of serum high-sensitivity C-reactive protein, procalcitonin, and white blood cell count for infection in maintenance hemodialysis patients LONG Song, LI Fu-liang, YANG Jin-you, DENG Fu-wen 2024, 23 (08):  601-604.  doi: 10.3969/j.issn.1671-4091.2024.08.006 Abstract ( 116 )   PDF (492KB) ( 12 )   Objective  To explore the diagnostic value of high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and white blood cell count (WBC) in maintenance hemodialysis (MHD) patients combined with infection.  Methods  The MHD patients hospitalized in the Blood Purification Center of Honghe First People's Hospital from January 1, 2022 to December 31, 2023 were enrolled in this study. They were divided into infected group and non-infected group. Serum hs-CRP, PCT and WBC count were measured and compared between the two groups. The efficacy of the three indexes for the diagnosis of infection in MHD patients was evaluated by receiver operator characteristic (ROC) curve.   Results  A total of 136 patients were included in this study (70 patients in infected group, and 66 patients in non-infected group). Hospitalization day (t=-6.706, P<0.001) and hospitalization expenses (t=-5.592, P<0.001) were higher in the infected group than in the non-infected group. Serum hs-CRP (t=-7.021, P<0.001), PCT (t=-6.063, P<0.001) and WBC (t=-3.218, P=0.001) were higher in the infected group than in the non-infected group. The diagnostic value of hs-CRP was higher than that of PCT and WBC for the infection in MHD patients. If the cutoff value of hs-CRP was set at 16.25 mg/L, the area under the curve (AUC) corresponding to the maximum entry index was 0.849, with the sensitivity of 83.33%, and the specificity of 75.71%. Serum hs-CRP combined with PCT had the best diagnostic efficacy, with the AUC corresponding to the maximum boarding index of 0.882, the sensitivity of 89.39%, and the specificity of 74.29%; serum hs-CRP combined with PCT and WBC had a better diagnostic efficacy, with the AUC of 0.878, the sensitivity of  83.33%, and the specificity of 80.00%.  Conclusion   Combined use of hs-CRP, PCT and WBC have a better diagnostic value, and can be used as a clinical reference to initiate antimicrobial treatment in MHD patients complicated with infection. Metrics

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Role of blood magnesium in mineral and bone disorders related to chronic kidney disease BAI Wei-wei, DU Shu-tong, MA Wei-hua, WANG Ya-jing, WANG Na 2024, 23 (08):  605-608.  doi: 10.3969/j.issn.1671-4091.2024.08.007 Abstract ( 96 )   PDF (422KB) ( 20 )   Chronic kidney disease (CKD) mineral and bone disorder (CKD-MBD) is a common complication in CKD patients. CKD-MBD as a systemic disease is involved in a variety of mineral and bone metabolism abnormalities such as changes in bone density and bone strength and vascular calcification, contributing to an important impact on quality of life and long-term prognosis of the patients. Although our understanding of the pathogenesis of CKD-MBD has been improved for many years, blood magnesium on the evolution of CKD-MBD has not been appreciated until recent years. Studies have found that blood magnesium and CKD-MBD may be closely related, but the available data remain to be equivocal. Further studies are required to confirm these findings. In this paper, the physiological function of magnesium, the relationship between magnesium and CKD and CKD-MBD, and their interactions are reviewed. We suggest that regulation of blood magnesium level may be a new target for the treatment of CKD-MBD. Metrics

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Research advances in  the mechanism of autogenous arteriovenous fistula stenosis LIANG Xin-yi, WANG Tao-xia, LIU Xiao-li, RONG Dan, CAI Xiao-bei, LI Gui-ying 2024, 23 (08):  609-611,640.  doi: 10.3969/j.issn.1671-4091.2024.08.008 Abstract ( 233 )   PDF (506KB) ( 114 )   Autogenous arteriovenous fistula (AVF) is the vascular access most commonly used for hemodialysis (HD) patients. In clinical practice, the prevalence of AVF stenosis is 4.6% to 10.8%. Therefore, exploring the mechanism of AVF stenosis is of vital significance to prolong the blood the access period of AVF and to improve the quality of life in HD patients. This article briefly introduces the autogenous AVF stenosis and its classification, and summarizes the research progresses in the mechanism of AVF stenosis, including vascular smooth muscle cell proliferation, platelet aggregation and thrombus formation, inflammatory reaction, hemodynamic shear force, hypoxia, immune system, genetics and individual differences. The presence of AVF stenosis is the interaction results of multiple factors. A deep understanding of these mechanisms contributes to the development of effective diagnostic and therapeutic strategies to increase the patency rate of AVF in HD patients. Metrics

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Research progress in the assessment tools and influencing factors of somatic frailty in patients with maintenance hemodialysis ZHU Zheng-wei, ZHANG Jian-jun, CAO Hui-ting, SUN Yi-shen, TAO Xing-juan 2024, 23 (08):  612-615.  doi: 10.3969/j.issn.1671-4091.2024.08.009 Abstract ( 107 )   PDF (461KB) ( 18 )   Maintenance hemodialysis (MHD) patients are often associated with somatic frailty, which leads to a variety of adverse clinical outcomes and causes significant threats to the quality of life and life safety of the patients. Frailty is a complex syndrome usually involving somatic, cognitive and social aspects, which are interconnected and interacted each other. The incidence of somatic frailty is high, and it is usually associated with cognitive and social frailty. The progression of frailty can be alleviated or reversed, if assessment and intervention are made at an early stage. This paper reviews the assessment tools and influencing factors for somatic frailty, with the aim of providing references for the development of frailty interventions for MHD patients in China. Metrics

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Effect of blood pressure variability on graft arteriovenous fistula function CHEN Shuang-shuang, ZHOU Jian-fang, HU Ting, YOU Jin-ding, HUANG Jia-li 2024, 23 (08):  616-619.  doi: 10.3969/j.issn.1671-4091.2024.08.010 Abstract ( 99 )   PDF (503KB) ( 8 )   Objective  To investigate the effect of blood pressure variability on the function of arteriovenous graft (AVG) in hemodialysis patients.  Methods A retrospective study was conducted to collect patients who used AVG as vascular access in December 2020. Blood pressure variability during hemodialysis for 4 consecutive weeks (12 times in total) was analyzed, and the patients were divided into control group (blood pressure variability >17.3, n=40) and observation group (blood pressure variability ≤17.3, n=40) according to the median blood pressure variability. The incidence of thrombosis and auxiliary primary patency rate were observed to explore their correlation.  Results  A total of 80 patients were included, and the clinical data within one year were observed. The AVG thrombosis rates in the control group and the observation group were 77.5% (31/40) and 22.5% (9/40), respectively, and the difference between the two groups was statistically significant (χ²=24.200, P<0.001). The 12-month auxiliary primary patency rate in the control group was lower than that in the observation group (Log-rank, χ²=63.870, P＜0.001).  Conclusion  The author believes that the higher the blood pressure variability, the greater the hemodynamic changes, and the higher the risk of thrombosis in AVG. It is recommended to evaluate blood pressure variability in dialysis regularly, and take targeted intervention measures to reduce thrombosis in AVG and improve the auxiliary primary patency rate. Metrics

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Effect of  overlock stitch for vascular anastomosis during internal fistula surgery on patency of the arteriovenous fistula LI Li-hua, WANG Wei-hua, LI Mei, ZHANG Xuan 2024, 23 (08):  620-624.  doi: 10.3969/j.issn.1671-4091.2024.08.011 Abstract ( 84 )   PDF (506KB) ( 10 )   Objective  To investigate the effect of overlock suture for vascular anastomosis during internal fistula surgery on postoperative patency of the internal arteriovenous fistula (AVF).  Methods  A retrospective analysis was performed on 256 patients who received vascular anastomosis surgery for AVF construction in our hospital from July 2020 to June 2023. They were divided into two groups according to the stitch method: the traditional manual stitch group using manual stitch (n=178), and the overlock stitch group using a stitch instrument for stitch (n=78). The two groups were matched 1:1 with 64 patients in each group by propensity score matching (PSM) method. The efficacy and complications after the treatment were compared between the two groups. According to the patency of AVF after the surgery for 6 months, the 128 patients were divided into patency group (n=81) and poor patency group (n=47). Univariate and multivariate logistic regression were used to analyze the independent influencing factors for poor AVF patency. A risk assessment scale and risk stratification were conducted, and the predictive value of the risk assessment scale were verified.  Results After the surgery for one month and 6 months, anastomotic diameter (t=22.936 and 24.078, P<0.001), blood flow in AVF (t=12.990 and 14.009, P<0.001) and AVF patency rate (χ2=5.489 and 6.646, P=0.019 and 0.010) were better in the matched overlock stitch group than in the matched traditional manual stitch group. Postoperative complication rate was lower in the matched overlock stitch group than in the matched traditional manual stitch group (χ2=19.384, P<0.001). Multivariate logistic regression showed that mean arterial pressure ≥70mmHg (OR=3.355, 95% CI: 1.502～7.492, P=0.003), preoperative internal diameter of the anastomotic artery <3.5mm (OR=2.344, 95% CI: 1.124～4.888, P=0.023) and preoperative internal diameter of anastomotic vein <3.5mm (OR=2.177, 95% CI: 1.048～4.525, P=0.037) were the independent risk factors for poor postoperative patency of AVF, while hypertension history (OR=0.114, 95% CI: 0.049～0.265, P<0.001), diabetes history (OR=0.357, 95% CI: 0.168～0.759, P=0.007) and blood phosphorus ≤1.78mmol/L (OR=0.501, 95% CI: 0.239～1.047, P=0.006) were the protective factors for postoperative AVF patency. Using scores of 3 points in the risk assessment scale as the optimal cutoff value for diagnosis, the sensitivity and specificity were 79.8% and 73.2% respectively; scores of ≤2.5 points were classified as low risk, 3.0～4.0 points as medium risk, and ≥4.5 points as high risk of poor patency. Using the 120 patients treated between July 2022 to June 2023 to verify the diagnostic value of the assessment scale and showed that the sensitivity, specificity, positive predictive value, and negative predictive value of poor patency were 79.6%, 78.9%, 70.6%, and 85.6% respectively.  Conclusion The overlock suture technique for vascular anastomosis in the surgery of AVF construction can significantly improve the postoperative patency of the AVF. Overlock stitch technique provides a stable and reliable anastomosis and reduces the risk of postoperative complications. Metrics

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Construction of a caring management program for peritoneal dialysis patients based on best evidences CAO Pei-ye, ZHAO Hui-ping, WU Bei, LU Li-xia, QIAO Jie, CHU Xin-xin, MEN Chun-cui, HE Yu-ting 2024, 23 (08):  625-629.  doi: 10.3969/j.issn.1671-4091.2024.08.012 Abstract ( 88 )   PDF (484KB) ( 12 )   Objective To construct a caring management program for peritoneal dialysis (PD) patients, and to provide theoretical reference for medical staff to conduct long-term caring management for PD patients.  Methods The caring management program for PD patients was first drafted based on the systematic retrieval of domestic and foreign evidences and guided by the best evidences of the management for PD patients. Thirty-four experts were then consulted by Delphi method to obtain their advices and clinical experiences. The caring management program was finally constructed between September to October 2022.  Results  In the two rounds of consultation by mails, the effective response rates were 89.47% and 97.06%, and the authority coefficients of experts were 0.936 and 0.942. In the second round of consultation by mails, the coordination coefficients of experts to the first and second levels of indicators were 0.248 and 0.145, respectively (P＜0.001). The caring management program for PD patients consisted of 7 first level indicators and 48 second level indicators.  Conclusion To further improve the effectiveness of treatment at home and the quality of life of PD patients, we have constructed a care management program for PD patients using the Delphi method. This program can serve as a reference of clinical guidance for medical staff. However, the practical value and clinical benefits of the program need to be further verified. Metrics

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Construction of a core competence evaluation index system for nurses specializing in continuous renal replacement therapy XU Xian-rong, ZHU Ya-mei, WANG Mi, XU Jing, YE Ya-jun, CAO Shi-qi, WU Bu-yun, MAO Hui-juan 2024, 23 (08):  630-635.  doi: 10.3969/j.issn.1671-4091.2024.08.013 Abstract ( 117 )   PDF (501KB) ( 35 )   Objective  To construct a core competency evaluation index system for nurses specializing in continuous renal replacement therapy (CRRT).  Methods   The first draft of core competence evaluation indexes for CRRT nurses was formulated by referring to domestic and international literature and after discussion in the research group. The second round of consultation with 16 experts was conducted from June to August 2023 by using the Delphi method, to complete the screening and modification of the indexes and to determine the weights of the indexes.   Results  The finalized core competency evaluation indicators for CRRT nurses included 7 first-level indicators (professional theoretical knowledge, professional practical ability, critical thinking ability, communication and coordination ability, management ability, professional development ability, and professional humanistic literacy ability), 27 second-level indicators, and 112 third-level indicators. The effective response rate of the two rounds of expert consultation was 100%, and the expert authority coefficient was 0.912. The Kendall harmony coefficients of the first-, second-, and third-level indicators of the second round of correspondence were 0.399, 0.278, and 0.208, respectively, and the results of the correspondence were all P<0.001.  Conclusion  The constructed core competency evaluation indexes for CRRT specialized nurses are scientific, rational, comprehensive, and professional. This evaluation index system can be used for the training and evaluation of CRRT specialized nurses. Metrics

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The mediating effect of self-perceived burden on empowerment and quality of life in peritoneal dialysis patients ZHANG Ying, SHI Xue-zhi, GUAN Yu-xiang, ZHENG Jing, WANG Chao 2024, 23 (08):  636-640.  doi: 10.3969/j.issn.1671-4091.2024.08.014 Abstract ( 96 )   PDF (555KB) ( 20 )   Objective  To investigate the status quo of empowerment, self-perceived burden and quality of life in peritoneal dialysis (PD) patients, and to analyze the mediating effect of self-perceived burden.  Methods  A total of 235 PD patients hospitalized in the First Affiliated Hospital of Anhui University of Chinese Medicine from November 2022 to May 2023 were selected by convenience sampling method as the study objects. Simplified peritoneal dialysis empowerment scale, self-perceived burden scale and kidney disease quality of life scale were used for the investigation. SPSS 26.0 was used to analyze the correlation between empowerment, self-perceived burden, and quality of life. AMOS24.0 was used to establish a structural equation model, and bootstrap method was used to test the model.   Results  The total score of empowerment in PD patients was 22.83±4.20, the total score of self-perceived burden was 33.03±6.18, and the total score of quality of life was 45.35±5.26. The self-perceived burden was negatively correlated with the total score of empowerment (r=-0.401, P<0.001) and the total score of quality of life (r=-0.426, P<0.001). Empowerment ability of the PD patients directly and positively affected the quality of life. Self-perceived burden played a partial mediating role between empowerment and quality of life (β=0.203, P<0.001), and the mediating effect accounted for 27.78% of the total effect.  Conclusion  The empowerment ability and self-perceived burden of the PD patients were in the medium level, and the quality of life was in the lower middle level. The self-perceived burden had a partial mediating effect between the empowerment ability and the quality of life. We suggest that medical staff should strengthen the empowerment education of the patients, stimulate their inner strength, reduce the self-perceived burden of patients, and improve their quality of life. Metrics