Abstract: 【Abstract】 Objective　To explore the therapeutic effect of plasma exchange in the treatment of patients with dermatitis medicamentosa like of trichloroethylene(DMLT) accompanied with severe hepatitis．Methods 21 patients were treated with plasma exchange on the basis of conventional therapy．The hepatic function makers，coagulation tests and improvements of clinical symptoms were compared．Results After treatment，the patients total bilirubin，alanine aminotransferase，aspartate amino transferase，Tumor necrosis factor-α，prothrombin time decreased(P<0.05)，albumin increased(P<0.05)，and clinical symptoms improved. There were no significant difference in activeated partial thromboplastin time、thrombin time and Human Fibrinogen．The effective rates were 100%. 1 patient died of pulmonary infection because of Nocadia. 20cases(95.2%) out of the 21 patients survived. 81 times of plasma exchange treatments were done in all 21 cases，and that with adverse reaction was 2 times．Conclusions　Plasma exchange is safe and effective in treatment of patients with DMLT．

Key words: Plasma exchange(PE), dermatitis medicamentosa like of richloroethylene(DMLT), severe hepatitis