Abstract: Abstract:Objective: To demonstrate the value of urinary angiotensinogen (UAGT) in renal function in those diabetic patients who without hypertension. Methods: Single centre and cross section study. 102 DM Patients who were hospitalized in Peking University third Hospital from September 2012 to December 2012，had not received ACEI or ARB treatment. Desided by UALB-creatinine ratio (UALB/Cr) devided the patients into three groups: urine protein negative group, microalbuminuria group, macroalbuminuric group. And 18 health people selected to be the control group. To recorded patients’ gender, age, blood pressure, renal function, urinary protein and measured angiotensinogen by ELISA. Results: UAGT–creatinine ratio (UAGT/Cr) UAGT/Cr was significant raised(p < 0.001) in urine protein negative DM group than the control group. At the same time with the diastolic blood pressure significant raised and eGFR significant decreased. (p<0.01). This tendency was more obviously in macroalbuminuric DM group. The result of correlation analysis indicated that UAGT/Cr was the single factor with diastolic blood pressure and UALB/Cr（p<0.01）. Regression analysis indicated that the UAGT was the negative factor for eGFR in DM patients. Conclusion: These data indicate that UAGT was increased in urine protein negative DM patients who without hypertension, and more increased in diabetic nephropathy. The elevator of UAGT maybe correlated with the progress of damage of renal function in diabetic nephropathy patients. The UAGT may to be a marker for prognosis renal damage in diabetic patients.

Key words: Diabetes mellitus, urinary protein, urinary Angiotensinogen