Abstract: 【Abstract】Objective To investigate the effects of a 12-week intradialytic aerobic exercise on the oxidative stress and quality of life in maintenance hemodialysis (MHD) patients，in order to guide the clinical practice of exercise in dialysis patients.Methods 34 MHD patients from the hemodialysis center of Shenzhen People's Hospital were recruited for exercise group (27 patients completed this study). Other 27 patients were selected as the control group. A 12- week intradialytic aerobic exercise program in which subjects exercised 3 times a week (cycle ergometer, mini-stepper) for 45 minutes in each of the first 2 hours of hemodialysis, and the control group did not take any intervention. The prescription of exercise intensity was based on Borg’s Perceived Exertion Scale. General information, the oxidative stress indicators, and The Medical Outcomes Study Short Form 36-item (SF-36) questionnaire were performed at baseline and following the intervention. Results Seven cases quited in the exercise group. No serious adverse events happened in all subjects during the test. After 12-week intradialytic aerobic exercise, serum advanced oxidation protein products (AOPP) significantly decreased from 21.97 ± 3.04μmol / L to 18.12 ± 2.76μmol / L (t=12.567, P 0.05). Significant improvement in physical function (PF), bodily pain (BP), general health (GH)and physical component scale(PCS) was obtained in patients of treated group, while the role physical (RP), vitality (VT), social function (SF) , role emotional (RE) ,mental health (MH) and mental component scale remained unchanged. Conclusion A 12-week intradialytic aerobic exercise could reduce the oxidative stress products, enhance the ability of anti-oxidative stress and improve the quality of life in MHD patients. No severe advers effects were found.

Key words: Hemodialysis, Oxidative stress, aerobic exercise