Abstract: 【Abstract】 Objective To investigate the effect of continuous renal replacement therapy (CRRT) on heat stroke (HS) patients complicated with rhabdomyolysis (RM). Methods Six patients with severe heat stroke and RM were treated with CRRT combined to other comprehensive measures. Their therapeutic effects and prognosis were evaluated. Results After the treatment, 5 of the 6 patients recovered and discharged from the hospital and one patient died. In the 5 recovered patients, vital signs improved significantly after CRRT therapy for 24h, 48h, and 7 days as compared with the clinical conditions before CRRT; heart rate (F=19.987, P=0.000), body temperature (F=52.979, P=0.000), and APACHE II scores (F=64.904, P=0.000) decreased; the Glasgow coma score (GCS) (F=28.818, P=0.000) and mean arterial blood pressure (F=5.391, P=0.009) increased; serum myoglobin (F=55.605, P=0.000), phosphokinase (F=64.904, P=0.000), alanine aminotransferase (F=8.503, P=0.001), aspartate aminotransferase (F=8.166, P=0.002), creatinine (F=9.296, P=0.001), lactate dehydrogenase (F=91.839, P=0.000), C-reactive protein (F=10.852, P=0.000), serum potassium (F=23.678, P=0.000) concentrations decreased. Conclusions CRRT is one of the effective approaches for emergent treatment of HS patients complicated with RM. CRRT can be well tolerated and can improve the prognosis of HS patients complicated with RM.

Key words: Renal replacement therapy, Heat stroke, Rhabdomyolysis