Abstract: 【Abstract】Objective To investigate the effects of short-term high frequency hemoperfusion on skin pruritus in regular hemodialysis patients. Methods Fifteen regular hemodialysis patients were treated with hemoperfusion combined with hemodialysis (HP+HD), three times a week for 2 weeks. Before and after the treatment, symptoms and scores of skin pruritus were evaluated, and biochemical parameters were collected. Results After the first HP+HD treatment the remission rate of skin pruritus was 66%, and after the last treatment the remission rate was 100%. After the first treatment, skin pruritus score (9.5±6.2) was lower than that before the first treatment (24.9±6.9; P0.05). We did not found any adverse effect. Conclusions Short-term high frequency hemoperfusion combined with hemodialysis can effectively and quickly relieve skin pruritus and improve quality of life in regular hemodialysis patients.

Key words: skin pruritus, hemodialysis, hemoperfusion