Abstract: 【Abstract】Objective To investigate the clinical characteristics and single nucleotide polymorphisms of the receptor for advanced glycation end product (RAGE) in peritoneal dialysis (PD) patients with intrinsically high peritoneal transport rate in the peritoneum. Methods During the period from January 2011 to June 2014, 194 newly started PD patients were included in this study. Patients were divided into four groups: low (L), low average (LA), high average (HA), and high (H) peritoneal transport rate groups, according to their categories of peritoneal transport rate defined by the result of peritoneal equilibration test (PET) at 8-12 weeks after PD. The clinical data and RAGE genotypes were compared across the groups. Multiple logistic regression analysis (backward stepwise) was used to determine the independent factors associated with high peritoneal transport rate. Results Significant difference in gender, history of cardiovascular complications, and serum C-reaction protein level were found among the groups (P＜0.05). Among the four most common polymorphisms in RAGE gene, only -374T/A polymorphism was found to be associated with the peritoneal transport status. RAGE -374TA/AA genotype had a significantly lower prevalence in patients with H/HA transport status than did -374T/T genotype (P＜0.05). Logistic regression analysis showed that the history of cardiovascular complications, serum C-reaction protein level, and RAGE -374T/A polymorphism were the independent risk factors for high peritoneal transport rate (P＜0.05). Conclusion The history of cardiovascular complications, higher serum C-reaction protein level, and RAGE -374T/A polymorphism may be useful markers in predicting
the high peritoneal transport rate before PD.

Key words: Peritoneal dialysis, high peritoneal transport rate, receptor for advanced glycation end product, gene polymorphism