Abstract: 【Abstract】Objective To investigate the relationship between high ankle-brachial index (ABI) and major adverse cardiovascular events (MACE) in patients on peritoneal dialysis (PD). Methods A total of 98 chronic kidney disease patients treated with PD over 3 months were recruited. Baseline characteristics, ABI,
Framingham cardiovascular risk factors and other laboratory measurements were collected and analyzed. Results Patients were divided into two subgroups according to ABI value. Among these participants, 33 participants (one-side or two-sides ABI＞1.3) were assigned in high ABI group and the other 65 participants (0.9＜two-sides ABI＜1.3) were assigned in normal ABI group. Twenty-eight patients suffered MACE. PD patients with high ABI had higher incidence of MACE than those with normal ABI (15/33 vs. 13/65, P=0.008). Compared with normal ABI group, patients in high ABI group had significantly higher dialysis age, blood pressure, serum calcium, ischemia modified albumin (IMA) and high sensitivity C-reactive protein (hs-CRP), and lower serum albumin, residual GFR (rGFR) and 24h urine volume. According to Framingham cardiovascular risk factors, all of the PD patients could be divided into three groups: cardiovascular disease (CVD) 0~1 group (36 participants with 0~1 Framingham cardiovascular risk factor), CVD 2~3 group (40 participants with 2~3
Framingham cardiovascular risk factors), CVD 4 group (22 participants with more than 4 Framingham cardiovascular risk factors). The prevalence of high ABI was statistically different among the three groups (19.444%, 27.500% and 68.181%; chi square=15.676, P=0.000). Logistic regression analysis showed that dialysis age, serum calcium, IMA level and hs-CRP level were the independent risk factors for high ABI. Conclusions High ABI was closely related to cardiovascular events in PD patients. Dialysis age, serum calcium, oxidative stress and inflammation were the most important factors for high ABI.

Key words: Ankle-brachial index, Peritoneal dialysis, Arterial calcification, Major adverse cardiovascular events