Abstract: 【Abstract】Star fruit contains neurotoxins that often cause intoxication with high mortality in chronic renal disease patients. Clinical manifestations of star fruit intoxication include hiccup, nausea, vomiting, limb numbness, consciousness disturbance, seizure and coma. The neurotoxin of star fruit is a liposoluble molecule called caramboxin, which has potent excitatory, convulsant and neurodegenerative properties. Currently, there is no consensus about the optimal strategy against star fruit intoxication. Comprehensive treatment strategy may be necessary and blood purification may be useful. In this paper, we introduce the pathogenesis, clinical manifestations, diagnosis and treatment of star fruit intoxication.

Key words: Star fruit, Hiccup, Neurotoxicity, Chronic renal disease, Dialysis