Abstract: 【Abstract】To investigate the relationship between increased left ventricular mass index (LVMI) and other risk factors and decreased cognitive function in end- stage renal disease (ESRD) patients. Methodology We recruited 39 chronic kidney disease patients at stage 5 without dialysis and hospitalized in the Department of nephrology, the first affiliated Hospital of Xi'an Jiaotong University in the period from June 2016 to December 2017. Patient's demographic data, color Doppler echocardiography findings, neuropsychological scale (the Montreal cognitive scale, MoCA) to evaluate the overall cognition function, and the executive function score (connection test A) were collected. Correlation analysis and multivariate regression were conducted to analyze their demographic data, cardiac color Doppler ultrasound findings and cognitive function scores. Results ①The correlation analysis between demographic data and cognitive score showed that age was positively correlated with connection test A score (r=0.335, P=0.037); education level and serum calcium were negatively correlated with connection test A score (r=-0.546 and -0.358 respectively, P=0.001 and 0.025 respectively) and were positively correlated with MoCA score (r=0.593 and 0.349 respectively, P=0.001 and 0.030 respectively); cystatin C was negatively correlated with MoCA score (r=-0.398, P=0.012). ②The correlation between left ventricular diameter and function and cognitive score showed that LVMI was positively correlated with connection test A score (r=0.471, P=0.003) and negatively correlated with MoCA score (r=-0.332, P=0.039).③Multivariate stepwise regression analysis showed that education level and LVMI were closely related to the decrease of executive function in ESRD patients (t=-3.891 and 3.238 respectively, P=0.001 and 0.003 respectively); education level, cystatin C and LVMI were closely related to the decrease of overall cognitive function in ESRD patients (t=0.516, -1.496 and -0.022 respectively, P=0.001, 0.004 and 0.021 respectively). Conclusion Many factors affect the cognitive function, and increased LVMI may closely relate to the decreased cognitive function in ESRD patients.

Key words: end stage renal disease, left ventricular mass index, cognition