Abstract: 【Abstract】Objective To explore the related factors of unscheduled interruption during prolonged intermittent renal replacement therapy (PIRRT). Method The medical records of all patients received PIRRT in the Renal Department of Peking University First Hospital from January 2017 to December 2017 were retrospectively reviewed. Circuit and patient data were collected and analyzed. Result A total of 82 patients with 898 circuits were finally included in this study, in which 259 circuits (28.8%) were considered as unscheduled interruption. Circuit clotting was observed in 212 cases of the unscheduled interruption (81.9%). Compared to the scheduled group, the unscheduled group was more likely not to receive anticoagulation (34.7% vs. 13.3%,
χ2=71.941, P<0.001), to use femoral vein catheters (68.3% vs. 59.8%, χ²=5.745, P=0.010), and to have higher level of the highest filtration fraction (31.7±5.3% vs. 31.0±4.6%, t=-1.985, P=0.047). There were no significant differences in the education degree of nurses (62.9% vs. 64.9%, χ²=0.304, P=0.318), working years of nurses (3.3 ± 2.0 vs. 3.6 ± 2.1, t=- 0.971, P=0.064), and patient- nurse ratio (1.8 ± 0.7 vs. 1.9 ± 0.8, t=- 1.833, P=0.360) between the two groups. Conclusion The main reason for unscheduled interruption during PIRRT in our dialysis center was circuit clotting caused by inappropriate use of anticoagulation, higher filtration fraction and catheter malfunction. After regular and standardized training, the education degree and working years of nurses had no significant impact on unscheduled interruption.

Key words: Renal replacement therapy, Anticoagulation, Filtration fraction, Circuit life