Abstract: Objective  To investigate dual-specificity phosphatase 6 (Dusp6) in peripheral blood combined with clinical parameters to predict all-cause death and cardiovascular event death in maintenance peritoneal dialysis (PD) patients.  Methods  Patients who underwent PD catheterization and maintenance PD were selected for the single-center and prospective cohort study. Dusp6 in peripheral blood was measured. Baseline clinical data, all-cause death and cardiovascular event death were collected. Kaplan-Meier method was used to compare the mortality of PD patients with different levels of Dusp6. Cox regression model was used to analyze the influencing factors for all-cause death and cardiovascular event death. ROC curve was used to evaluate the predictive indicators for all-cause death and cardiovascular event death.   Results  A total of 138 PD patients were included and followed up for 19 (15, 23) month. There were 48 all-cause death cases (34.78%) and 26 cardiovascular death cases (18.84%). The median level of Dusp6 in peripheral blood was 38.9pg/ml. The all-cause mortality and cardiovascular event mortality in patients with peripheral blood Dusp6 ≥38.9pg/ml were higher than in those with Dusp6 ＜38.9 pg/ml (χ²=17.5, P＜0.001; χ²=10.56, P=0.001). Age, low density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP) and Dusp6 were the influencing factors for all-cause death (HR=1.104, 3.105, 21.929 and 1.075 respectively; 95% CI:1.021～1.193, 1.069～9.013, 6.280～76.575 and 1.008～1.147 respectively; P=0.013, 0.037, ＜0.001 and 0.028 respectively); when combined the 4 influencing factors to predict all-cause death, the sensitivity and specificity were 81.11% and 80.17% respectively. Age, uric acid, CRP and Dusp6 were the influencing factors for cardiovascular event death; when combined the 4 influencing factors to predict cardiovascular event death, the sensitivity and specificity were 81.25% and 80.77% respectively.  Conclusion  The high expression of Dusp6 in peripheral blood is associated with all-cause death and cardiovascular event death in PD patients. The combination of Dusp6 and other related clinical parameters has better predictive values for all-cause death and cardiovascular event death in PD patients.

Key words: Maintenance peritoneal dialysis, Dual-specificity phosphatase 6, All-cause death, Cardiovascular event death, Influencing factor, Prediction