Abstract: Chronic kidney disease (CKD) mineral and bone disorder (CKD-MBD) is a common complication in CKD patients. CKD-MBD as a systemic disease is involved in a variety of mineral and bone metabolism abnormalities such as changes in bone density and bone strength and vascular calcification, contributing to an important impact on quality of life and long-term prognosis of the patients. Although our understanding of the pathogenesis of CKD-MBD has been improved for many years, blood magnesium on the evolution of CKD-MBD has not been appreciated until recent years. Studies have found that blood magnesium and CKD-MBD may be closely related, but the available data remain to be equivocal. Further studies are required to confirm these findings. In this paper, the physiological function of magnesium, the relationship between magnesium and CKD and CKD-MBD, and their interactions are reviewed. We suggest that regulation of blood magnesium level may be a new target for the treatment of CKD-MBD.

Key words: Magnesium, Chronic kidney disease, Mineral and bone abnormalities