Abstract: Objective To investigate serum C-reactive protein ( CRP)，interleukin-6(IL-6) level and their correlation with nutritional status in patients with end-stage renal disease(ESRD) undergoing peritoneal dialysis. Methods The serum levels of CRP，IL-6，albumin(Alb)，hemoglobin(Hb), transferin( TF)，serum creatinine(Scr) were determined in normal controls, patients without peritoneal dialysis and with peritoneal dialysis. The peritoneal dialysis patients were divided into CRP≤6 mg/L group and CRP＞6 mg/L group．Thc levels of IL- 6，Alb，Hb，TF and Scr were compared between this two groups. Results The serum CRP, IL-6 in peritoneal dialysis group were significantly higher than those of non-peritoneal dialysis group(P＜0.05) and normal control group (P＜0.01)． In peritoneal dialysis group CRP and IL- 6 were negatively correlated with Alb、Hb and TF，respectively (r＝-0.543～-0.379，P＜0.05)，but not correlated with Scr (r＝0.258、0.245，P＞0.05). Conclusion There is microinflammatory state with peritoneal dialysis in the ESRD patients. CRP and IL-6 are the better predictive markers of microinflammatory state and nutrition status.

Key words: C-reactive protein, Interleukin-6, Nutritional status