中国血液净化

中国血液净化 ›› 2020, Vol. 19 ›› Issue (03): 145-148.doi: 10.3969/j.issn.1671-4091.2020.03.001

• 贫血专题 •    下一篇

低氧诱导因子稳定剂在肾性贫血中的成功应用对未来的启示

刘必成1,李作林1,林善锬2   

  1. 1东南大学附属中大医院肾脏科；东南大学肾脏病研究所
    2复旦大学肾脏病研究所，复旦大学附属华山医院肾脏科

  • 收稿日期:2020-01-08 修回日期:2020-01-10 出版日期:2020-03-12 发布日期:2020-03-12
  • 通讯作者: 刘必成 liubc64@163.com E-mail:liubc64@163.com
  • 基金资助:
    国家重点研发计划(2018YFC1314000)；国家自然基金国际交流合作项目(81720108007)；国家自然基金面上项目(81670696)

The enlightenment from successful application of hypoxia inducible factor-prolyl hydroxylase inhibitor (HIF-PHI) in renal anemia

  1. 1Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210000, China;  2Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2020-01-08 Revised:2020-01-10 Online:2020-03-12 Published:2020-03-12

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摘要： 【摘要】红细胞生成素(erythropoietin，EPO)的调节是机体低氧适应的重要病理生理过程，对这一现象的深入探究发现了机体的氧感应调适系统。氧感知调适系统的发现为EPO 缺乏相关疾病的治疗提供了理论基础。靶向机体氧感受器—脯氨酰羟化酶(prolyl hydroxylase domain，PHD)研发的低氧诱导因子稳定剂(hypoxia inducible factor-prolyl hydroxylase inhibitor，HIF-PHI)将这一理论基础转化为临床应用。目前，HIF-PHI 主要用于肾性贫血的治疗，而HIF-PHI 使用对肾脏病以及相关疾病的影响尚不十分清楚。本文主要总结了HIF-PHI对贫血、各种肾脏病以及慢性肾脏病心血管疾病的潜在作用。

关键词: 氧感应系统, 低氧诱导因子稳定剂, 贫血, 肾脏疾病, 心血管疾病

Abstract:

【Abstract】Studies of the erythropoietin(EPO) regulation, an important pathophysiological response to hypoxia, have led to the discovery of oxygen sensing and adapting system. This discovery has provided a theoretical basis for the treatment of EPO deficiency-related diseases. The development of hypoxia inducible factor-prolyl hydroxylase inhibitor (HIF- PHI) through the targeting of prolyl hydroxylase domain (PHD) is a type of translational medicine based on this discovery. HIF-PHIs have used clinically for the treatment of renal anemia. However, the effects of HIF-PHI on kidney and its related diseases are largely unhnown. In this paper, we summarize the potential effects of HIF-PHI on anemia, kidney diseases and CKD-related cardiovascular disease.

Key words: Oxygen sensing system, HIF-PHI, Anemia, Kidney diseases, Cardiovascular diseases

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