Abstract: 【Abstract】Objective To study the effects of high flux hemodialysis on skin pruitus and some biochemical indexes in hemodialysis patients. Methods The study was perspective and self-controlled. A total of 44 patients on preservation low flux hemodialysis were selected. After changing to high flux dialysis, dialysis prescription was unchanged except the change of dialyzer. Ultrapure dialysate was implied. To compare the skin pruitus, afterdialysis serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH), albumin ( ALB ) , C – reactive protein (CRP) , hemoglobin (Hb),hematocrit(Hct%)level before changing to high flux hemodialysis and after 6,12months entering this study respectively by One-way ANOVA. Results The skin pruitus was improved significantly after changing to high flux hemodialysis 6 and 12 months (F=5.960，P=0.000). There were no differences of serum Cr, BUN, UA, Ca before and after changing to high flux hemodialysis (P＞0.05). But the differences of serum Hb, Hct%, ALB, iPTH, P，CRP were significantly before and after 6,12 months entering the study (P＜0.05). Conclusion The study show that using high flux
hemodialysis can improve skin pruritus, microinflammatory state, anima, abnormal calcium and phosphorus metabolism and life quality in hemodialysis patients probably.

Key words: High flux hemodialysis, Skin pruritus, Biochemical indexes