关键词: 肾性贫血, 治疗效果

Abstract: 【Abstract】Anemia is prevalent in chronic kidney disease (CKD) patients, but the control rate of anemia is unsatisfactory in Chinese CKD patients. The causes of poor effectiveness to renal anemia therapy are variable. The common causes of hyporesponsiveness to erythropoietin stimulating agents (ESA) are easily correctable, such as absolute iron deficiency, folate or vitamin B12 deficiency, hypothyroidism, ACEI/ARB drugs and less compliance to therapy. Several factors are potentially correctable, such as infection/inflammation, underdialysis, hemolysis, hemorrhages, hyperparathyroidism, pure red cell aplastic anemia, malignancy and malnutrition. Several factors are impossible to be corrected, such as hemoglobinopathies and bone marrow diseases. When hyporesponsiveness to ESA occurs, we should carefully search for causes and treat correctable factors. For patients remaining to be hyporesponsive to ESA after correction of treatable factors, individualized therapy according to the relative risk degree and benefit should be adopted.

Key words: renal anemia, treatment effect