中国血液净化

中国血液净化 ›› 2019, Vol. 18 ›› Issue (07): 495-498.doi: 10.3969/j.issn.1671-4091.2019.07.008

• 综述 • 上一篇    下一篇

慢性肾脏病患者认知功能研究现状及进展

钱玉珺1,郑可1,李雪梅1   

  1. 1. 北京协和医院肾内科
  • 收稿日期:2018-11-22 修回日期:2019-01-20 出版日期:2019-07-12 发布日期:2019-07-12
  • 通讯作者: 郑可kellyz_0_67@163.com E-mail:kellyz_0_67@163.com
  • 基金资助:
    中国医学科学院医学与健康科技创新工程“疑难性罕见病样本库的深度挖掘与利用”(2017-I2M-2-001)；
    中国肾脏病学青年医师研究基金

Cognitive Impairment in Patients with Chronic Kidney Disease

  1. 1Department of Nephrology, Peking Union Medical College Hospital, Beijing 100730, China
  • Received:2018-11-22 Revised:2019-01-20 Online:2019-07-12 Published:2019-07-12

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摘要： 【摘要】慢性肾脏病(chronic kidney disease,CKD)患者常发生神经系统损害，其中认知功能障碍的发病率高，不良危害大。而目前CKD 患者认知功能障碍的具体机制仍不十分清楚，可能与血管损伤机制、非血管损伤机制和血液透析过程等相关。其中非血管损伤机制包括尿毒症毒素、炎症因子、内分泌激素与维生素、电解质、酸碱因素、贫血等，其对中枢神经系统有直接毒性，可能调节神经递质及干扰脑的代谢，从而引起认知功能障碍。本文对CKD 患者的认知功能进行综述，以期提高临床医生对其的重视，为认知功能障碍的预防治疗提供依据。

关键词: 慢性肾脏病, 透析, 认知功能

Abstract:

【Abstract】Patients with chronic kidney disease (CKD) are frequently afflicted with neurological complications. Among those, cognitive impairment (CI) is common and negatively affects health-related quality of life and other health-related outcomes. While the pathophysiology and etiology are complex and far from completely understood, CI may relate with vascular injury and some non-conventional cardiovascular risk factors. Some other non- conventional risk factors caused by ESRD, like anemia, oxidative stress, homocysteinemia and microinflammation, may aggravate the CI. In addition, hemodialysis and peritoneal dialysis may impact the brain by various mechanisms.

Key words: Chronic kidney disease, Dialysis, Cognitive impairment

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