中国血液净化

中国血液净化 ›› 2019, Vol. 18 ›› Issue (09): 597-599.doi: 10.3969/j.issn.1671-4091.2019.09.004

• 专题与讲座 • 上一篇    下一篇

巨噬细胞对腹膜透析相关性腹膜纤维化研究进展

唐寒芬1,2,朱旭萍2,刘伏友1   

  1. 1. 中南大学湘雅二医院肾内科
    2. 中南大学湘雅二医院营养科
  • 收稿日期:2019-01-22 修回日期:2019-05-09 出版日期:2019-09-12 发布日期:2019-09-02
  • 通讯作者: 刘伏友lfy2061@163.com E-mail:lfy410@yahoo.com.cn
  • 基金资助:
    湖南省自然科学基金课题，课题编号为2019JJ50862

Research advances in the function of macrophages in peritoneal dialysis related peritoneal fibrosis

  1. 1Institute of Nephrology and 2Department of Nutrition, The Second Xiangya Hospital, Central South University, Changsha 410011, China
  • Received:2019-01-22 Revised:2019-05-09 Online:2019-09-12 Published:2019-09-02

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摘要： 【摘要】腹膜透析是终末期肾病患者的三大替代治疗方法之一。腹膜透析相关性腹膜纤维化是腹膜透析的主要并发症，也是腹膜透析治疗失败的重要原因之一。腹膜透析相关性腹膜纤维化主要发病机制有转化生长因子-β1 表达异常、微小RNA 表达异常以及上皮间质转化等。近年来，研究发现巨噬细胞在腹膜纤维化的发生和发展中发挥着重要的作用。本文主要就巨噬细胞对腹膜透析相关性腹膜纤维化的研究进展进行综述。

关键词: 腹膜纤维化, 巨噬细胞, 转化生长因子-β1, 上皮-间充质转化, 微小RNA

Abstract:

【Abstract】Peritoneal dialysis (PD) is one of the three effective treatments for end- stage renal failure. However, peritoneal fibrosis is an important complication in PD patients, and is one of the important causes leading to failure of PD. The pathogenesis of peritoneal fibrosis includes abnormal expressions of transforming growth factor- β1 and microRNA, epithelial- mesenchymal transition, etc. Recently, many studies report that macrophages play an important part in the occurrence and development of peritoneal fibrosis. This review focuses on the research advances in macrophage cells in the pathogenesis of PD related peritoneal fibrosis.

Key words: Peritoneal fibrosis, Macrophage, Transforming growth factor β1, Epithelial-mesenchymal transition, MicroRNA

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