中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (11): 823-826.doi: 10.3969/j.issn.1671-4091.2022.11.008

• 综述 • 上一篇    下一篇

动静脉内瘘血管钙化的研究进展

胡梦红   赵光本   于长青   陈吉林   林洪丽   

  1. 16011  大连，1大连医科大学附属第一医院肾内科
  • 收稿日期:2022-04-29 修回日期:2022-05-30 出版日期:2022-11-11 发布日期:2022-11-12
  • 通讯作者: 陈吉林 E-mail:chenjilin88@126.com
  • 基金资助:
    大连市高层次人才创新支持计划(2021RD01)

Research progress in vascular calcification of arteriovenous fistula

HU Meng-hong, ZHAO Guang-ben, YU Chang-qing, CHEN Ji-lin, LIN Hong-li    

  1. Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
  • Received:2022-04-29 Revised:2022-05-30 Online:2022-11-11 Published:2022-11-12
  • Contact: 116011 大连，1大连医科大学附属第一医院肾内科 E-mail:chenjilin88@126.com

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摘要： 动静脉内瘘(arteriovenous fistula，AVF)是维持性血液透析(maintenance hemodialysis，MHD)患者首选的血管通路。血管钙化(vascular calcification，VC)是导致AVF功能障碍的重要原因之一，并且增加患者透析不充分及死亡的发生风险。AVF血管钙化的发生是促钙化因素增强及抑制钙化因素减弱共同作用的结果，包括血流动力学紊乱、钙磷代谢异常、炎症及氧化应激等因素引起的复杂的病理生理过程。本文就AVF血管钙化的流行病学特点、病理生理、发病机制及防治等研究进展进行综述。

关键词: 动静脉内瘘, 血管钙化, 终末期肾病, 维持性血液透析

Abstract: Arteriovenous fistula (AVF) is the optimal vascular access for maintenance hemodialysis (MHD) patients. Vascular calcification (VC) is one of the important causes of AVF dysfunction, increasing the risks of dialysis inadequacy and death in the patients. Vascular calcification of AFV is a complicated process, resulting from the combined effects of pro-calcification factors and calcification inhibition factors, such as hemodynamic changes, calcium and phosphorus metabolism dysfunction, inflammation, oxidative stress, and others. In this paper, the epidemiological characteristics, pathophysiology, pathogenesis, and prevention of AVF vascular calcification are summarized.

Key words: Arteriovenous fistula, Vascular calcification, End stage renal disease, Maintenance hemodialysis

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